Kalinkina N. Damage of the cardiovascular system by anthracyclines: working out of criteria of early diagnostics and methods of farmacological correction

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0510U000105

Applicant for

Specialization

  • 14.01.11 - Кардіологія

26-01-2010

Specialized Academic Board

Д. 26.616.01

Essay

Results of studying of instrumental and laboratory parameters of cardiovascular system function and their interrelation at the patients receiving anthracyclines are submitted. The data of standard ECHO, stress ECHO, tissue Doppler ECHO, spiroveloergometry, ultrasonic dopplerography of vessels, change of a metabolism nitrogen oxide, levels of endotheline-1, natriuretic peptides and troponins are analyzed. New criteria of early diagnostics and risk factors of damages of anthracycline cardiomyopathy are revealed. The method of treatment and prevention of this pathology with use of nebivolol and trimetazidin is developed.

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