Gordienko A. Mechanisms of immune abnormalities in patients with myeloid and lymphoid leukemias.

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0511U000366

Thesis Registration Form

0511U000366.pdf

Applicant for

Specialization

  • 14.01.31 - Гематологія та трансфузіологія

26-04-2011

Specialized Academic Board

Д 26.612.01

State Institution "Institute of Hematology and Transfusiology NAMS Ukraine"

Essay

Scientific problem of a role of immune abnormalities in pathogenesis of acute myeloid leukemia (AML), chronic myeloid leukemia (CML), myelodysplastic syndrome (MDS) and B-cell chronic leukemia (B-CLL) is given. Low rxpression of B7 family molecules (B7.1/CD80, B7.2/CD86) by tumor cells and their ligand СD28 by T cells contributes to molecular mechanisms of tumor cells "escape" from immune surveillance in patients with AML, CML, MDS and B-CLL before the start of treatment. In patients with AML and B-CLL direct correlation of remission length and number of CD80, CD86-positive monocytes and CD3/28 lymphocytes is shown.

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Files

Автореферат Гордиенко.doc

Автореферат Гордиенко.doc

Диссертация Гордиенко.doc

Диссертация Гордиенко.doc

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