Koval S. Role of circulating neutrophilic granulocytes in mechanisms of abnormalities in systemic hemovascular regulation in preeclampsia of pregnancy

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0511U000416

Thesis Registration Form

0511U000416.pdf

Applicant for

Specialization

  • 14.03.04 - Патологічна фізіологія

26-04-2011

Specialized Academic Board

Д 26.198.01

Bogomoletz Institute of Physiology National of science of Ukraine

Essay

One of formerly unknown mechanisms in the pathogenesis of preeclampsia in pregnancy is established - participation of circulating neutrophilic granulocytes with development of extracellular lysosomal reaction in hemovascular regulation by means of systemic increase of the activity of angiotensin converting enzyme, which participates in the mechanism of the ACE-dependent regulation of vascular tone and initiation of platelet release reaction in circulating platelets, thus being one of the important pathogenetic links of a syndrome of disseminated intravascular coagulation. Important role of circulating neutrophilic granulocytes in the pathogenesis of this complication of pregnancy is shown by investigations of pregnant women and women during labor with preeclampsia. It is also confirmed by experimental studies on laboratory animals with stress and preeclampsia of pregnancy modeling and with application of selective myelodepression, by studies of human isolated neutrophilic granulocyte and platelet, by ultrastructural studies of circulating in blood of pre-eclamptic women neutrophilic granulocytes and platelets.

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автореферат.doc

дисертація--Литер_2011.doc

дисертація--Раздел 1.doc

дисертація--Раздел 9.doc

дисертація--Раздел2.doc

дисертація--Раздел3.doc

дисертація--Раздел4.doc

дисертація--Раздел5.doc

дисертація--Раздел6.doc

дисертація--Раздел6.doc

дисертація--Раздел7.doc

дисертація--Раздел8.doc

дисертація--вступ.doc

дисертація--выводы.doc

дисертація--табл3алб.doc

дисертація--табл7.doc

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