Rikalo N. Pathogenesis of chronic viral hepatitis B and C in children: age-old peculiarities, pathogenetical therapy (experimental and clinical study)

Dissertation is devoted to the study of age-old peculiarities of pathogenesis of chronic viral hepatitis B and C in children and development new approaches to pathogenetical treatment. First there are the studied changes of cytokine profile and immune status in children of different age with chronic viral hepatitis B and C, the mechanism of chronisation and predictors of unfavorable course were define. First there is discovering pathogenesis of forming of primary chronic viral hepatitis B and C in perinatal infection and age-old morphological features of lethal outcome. Cytofluorometry first investigated the mechanisms of nuclear damage and regeneration of hepatocytes in impubertal rats with chronic toxic hepatitis and the effect hepatoprotectors on these processes. The most effective hepatoprotectors, possessing regenerative and antiapoptotic activity determined. A new pathogenic ground approaches to the treatment of chronic viral hepatitis B and C in children according to age, aimed on the regulation of reparative regeneration of damaged liver.