Tsiselskiy Y. The dysbiotic aspects of pathogenesis, prevention and treatment of diabetic retinopathy

The thesis covers the results of the experimental substantiation of dysbiotic aspects of diabetes mellitus pathogenesis. Dysbiosis development in sugar loading and modeling of diabetes mellitus of 1 and 2 types is shown for the first time. Diabetic retinopathy in the experimental dysbiosis and during introduction of the intestinal endotoxin (lipopolysaccharide) was established by biochemical and histological methods. There was studied a protective role of the liver in the development of diabetes and dysbiosis; the therapeutic and preventive effect of hepatoprotectors in diabetes is presented. The application of regulators of microbiocenosis - prebiotics for the prevention and treatment of diabetic retinopathy is substantiated by the experiment and in clinic. The prebiotics peculiarities of polyphenol compounds (quercethyn, izoflavones, chlorogenous acid, the complex of polyphenol substances from Sophora and bilberries) were determined for the first time. There was shown the ability of these preparations to prevent the development of diabetic retinopathy. There were devised practical recommendations on the application of bioflavonoids and prebiotics in the complex treatment of patients with diabetic retinopathy. The methods of restoration of dysbiosis and its assessment with the original enzymatic method are proposed.