Tkachuk P. Development of theory and methods of construction of high informativity electroretinography means

The research object is a process of construction of elektroretinography systems with sufficient certainty to a human neyrotoxcisity risk assessment. The research purposwe is solving of the important scientific and applied problem - the development of theory and methods of construction of elektroretinography means. To reach of the reasearch purpose the methods of functional analyses, theory of stochastic processes, theory of systems, mathematical modelling and computer simulation, theory of measurements, statistical theory of decision making and methods of expert systems development. Scientific novelty is following: according to the analysis of the theoretical foundations of the construction and application of known elektroretinography methods and means put forward a new concept of ultra-low-intensity light stimulation of retina and the spectral correlation theory of signals base for mathematical modelling, selection, processing and recording of elektroretinosignals (ERS). As the first case are taking into account the cyclical dynamics and stochastics of ERS and grounded the necessity of application of the adaptive recursive optimal estimation of ERS when ultra-low-intensity light stimulation of retina is applied. With the sufficient speed of the electroretinogram (ERG) estimations its resolution and predicted reliability are reached. Substantiated methods of ERG classification and decision on membership of ERG to a class are considered. The practical values consist in installation of features of elektroretinography prototype expert system (ERGES) to assess risk neyrotokxicity apriori unknown factors and verification of hardware, algorithms and software elektroretinography system and results of its applications. Decreasing of the complexity of ERS processing through unification of the mathematical model of ultra-low-intensity retinography is achieved. At the same time minimize the number of heuristic search procedures and automote them. Decreasing to 100 times the intensity of stimulation reduced the duration of the retinal ERG-researches (in vivo) in the (7-10) times. Effect of increased noise levels while reducing the optimal treatment of ERS was obtained ERG with a resolution that provides reliable decision about the risk of intoxication. Implementation degree is that that results frind applications at the medical diagnostic center (Chernivtsi}; treatment-diagnostic center (Rivne); Institute of eyes deseases & tissues terapy named after V.P. Philatov (Odessa). The application fields of the research - evaluating of the functional state of the organism under the early stages of influence of neurotoxicants: drags, narcotics, dopings and nanoparticles are spread in the environment.