Levchenko L. Congenital pneumonia in premature newborn children; early and differential diagnostics

The dissertation of the research the increasing of the efficacy of early diagnostics of congenital pneumonia in premature newborn children with respiratory distress on the basis of the assessment of clinicoparaclinical, tensiometrical, rheological, biochemical, microbiological, histological and instrumental criteria of the main pathogenetic development mechanisms of congenital pneumonia and respiratory distress syndrome, the development and introduction of differential approach to these diseases in premature newborn children at early neonatal period. The considerable risk factors (AF> 50%) of congenital pneumonia origin in premature newborns at neonatal period are associated pathology of mother's gestational period.During the study of tensiometry indices of blood and pulmonary condensate on the 1st and 7th days of life the characteristic changes have been revealed (k1, k2, ?0, ??1, ??2, ??) for the groups of premature newborns with congenital pneumonia, RDS, congenital pneumonia + RDS, which reflected in early differential diagnostics of RD. The blood and pulmonary condensate rheology (E, ua1, ub1, ?a2, ?b2, ?, ?) on the 1st and 7th days of premature newborns' life has been studied. The characteristic changes for each examined group has been revealed and correlations have been estimated. Algorithm of early differential diagnostics of congenital pneumonia, RDS, congenital pneumonia + RDS (method of Vald-Genkin) has been developed and introduced in practice.