Zubkova O. Mild craniocerebral injury: substantiation of diagnostic criteria and complex treatment of patients using magnetic-laser therapy in acute period (clinical and experimental study).

The dissertation theoretically generalizes and provides new decision for the currently important research and practical problem of neurology: to improve the diagnostics and results of treating patients with mild craniocerebral injury (MCCI) in an acute period by developing and updating diagnostic methods and performing complex rehabilitation with the use of a new method of magnetic-laser therapy (MLT), upon analyzing the results of experimental and clinico-electrophysiological investigations. A clinico-experimental MCCI model has been created to study the morphological changes and clinical manifestations (with the use of neurologic, instrumental and electro-physiological investigations), taking place under magnetic-laser exposure (MLE). Specific features of MLE courses given in the bio-stimulating dosage were studied while cultivating the neurons obtained from different cerebral structures of the newly born rats. An experimental MCCI model was perfected on rabbits to elucidate the basic MLE mechanisms in an acute period of MCCI via studying the water-ion balance in tissues of the cerebral hemispheres and during electronic-microscopic investigations into the peculiarities of ultra-structural changes in the synaptic system of neurons in the cerebral cortical and mesencephalic regions of rabbits. On the basis of experimental studies the optimum method of performing MLT in an acute period of MCCI was identified and implemented into the clinical practice: to treat patients with cerebral concussion in an acute period as part of the complex rehabilitation therapy. An integrative analysis of the clinico-electrophysiological investigations data and standard complex otoneurologic examination of patients with MCCI in an acute period gave the grounds to determine early diagnostic and differential-diagnostic criteria of the vestibular analyzer functional disorders by the extent of changes in the latent peaks of the vestibular evoked potentials.