Koshoviy O. Contemporary approaches to the new remedies on the basis of the plants from Eucalyptus and Salvia genera creation

The thesis is devoted to the development of contemporary approaches to the detection of new plant sources of the biologically active compounds among the plants of Eucalyptus and Salvia genera for the creation of new remedies with antibacterial activity. By the study of the chemical composition, obtaining and standardization parameters, antimicrobial activity of the extracts it was proven that the plants from the Salvia genus can be alternative to eucalyptus for obtaining original anti-staphylococcus remedies, which will decrease the dependence on the import of national pharmaceutical producers. The morphologico-taxonomic and chemotaxonomic study of the Salvia genus was carried out. The groups of taxons containing 1,8-cineol, chemical profile of the genus, correlation connections between biologically active compounds and morphological signs of the genus were determined which is the basis of the purposeful search of the plant material for the pharmaceutical industry. The documentation for the eucalyptus leaves, sage leaves, methods of obtaining of thick modified extracts on the eucalyptus leaf and sage leaf basis using polyvalent metals sulphates was worked out, their chemical composition was studied. Dry extracts, forming nanomicelles in water, were obtained from the thick modified sage extracts. The methods of quality control for the obtained extracts were worked out.