Manasova G. Pathogenetic mechanisms of formation, prevention and treatment of bone tissue pathology in pregnant women with placental complex infection

The thesis is devoted to development of differentiated pathogenetically based approaches to diagnosis, prevention and treatment of the osteopenic syndrome in pregnant women with perinatal infection. On the basis of studying of the clinico-anamnestic features, data of ultrasonic densitometry, results of the calcium-phosphoric exchange examination, calcium-regulated hormones, remodeling markers, cytokine profile it is determined the influence of perinatal infections on the bone tissue condition; pathogenetic mechanisms of the osteopenic syndrome development are defined. The features of the adaptation period of newborns are studied and monitoring of dynamic and static functions formation in these children within the first year of life is carried out. The scientifically proved methods of diagnosis, prevention and treatment of osteopenic syndrome are developed and introduced into practice. It is offered to form risk groups on development of bone tissue pathology in the antenatal clinics. Application of the developed method made it possible to stabilize the bone tissue structural condition and to prevent further bone loss, to improve quality of life of patients. Wide introduction of the developed method has allowed to improve also perinatal outcomes for the mother and fetus, to decrease morbidity of newborns, to make positive influence on the osteomuscular system formation and development within the first year of life.