Levytska S. Molecular-genetic Predictors and Physiopathology Peculiarities of Forming of Children's Chronic Sinusitis

In thesis were evaluated genetics' and pathophysiology mechanisms of chronic inflammatory process development in children's paranasal sinuses (PNS) according to hereditarily conditioned production of IL-1beta і IL-4. It was established that in etiopathogenesis of chronic sinusitis dominated: a violation of colonization resistance of mucous membrane, steady nasal obstruction, IgE-associated diseases; frequent and prolonged episodes of respiratory viral infection with a background of early displays by antigens and sensitization; mutations of polymorphic regions of promoter areas of IL-1beta (С-511Т) and IL-4 (С-590Т) genes. The development of chronic inflammatory process in paranasal sinuses will be with prevailing of exudation in case of genetic determined decreased production of IL-1beta and with manifestation of chronic productive inflammation in case of inherited conditioned predominance of CD4+-2-immune reaction