Bogdanova I. Disturbances of homeostasis system at several flow stages of Parkinson's disease (clinical and pathogenetic evaluation and correction)

Clinical and experimental dissertation trail was done on the basis of the results of clinical, neurological, biochemical, statistical methods examination of the state of homeo-stasis in patients with Parkinson's disease at several flow stages and in rats with haloperi-dol-induced experimental model of Parkinson's disease. The complex of homeostasis cor-rection was proposed. In the pathogenesis of Parkinson's disease one of significant links is a complex of disturbances of the nervous, immune, endocrine and oxidant-antioxidant systems which maintain the homeostasis. All these require polysystemic approach for pathogenic therapy substantiation. There are hyperactivation stress realizing systems that occurs in the dynamics of the progression of Parkinson's disease against the background of suppression stress-limiting systems, decreasing immunological reactivity, the launch of intracellular and membrane mechanisms of stress - energy imbalance activation of free radical oxidation and antioxi-dant system depletion, intracellular metabolism shift toward predominance of catabolic processes over anabolic. Disturbances of homeostasis systems can justify methods for their correction, based on the using of antioxidants, amino acids and vitamin complexes, correc-tors of the adaptive-accommodative processes with the background of antiparkinsonal drugs. The efficacy of the proposed method is confirmed by positive dynamics of changes detected informative diagnostic and prognostic parameters of blood and urine. Early detec-tion of idiopathic Parkinson's disease process and the early onset of proposed preventive measures are necessary for a more favorable course of Parkinson's disease. This helps to prevent / slow / delay the need to further increase doses of levodopa as important risk fac-tor levodopa related complications.