Stasenko A. Violation of Th1-Th2 immunity in patients with purulent diseases and purulent complications of surgical interventions.

Thesis is identified immune disorders Th1-Th2 links that facilitate the course of purulent-septic complications. It was found that patients with purulent diseases and purulent-septic postoperative complications developing combined disorders of the immune system, including the lack of T-cell immunity, which is characterized by decreased CD3+-lymphocytes, stimulation of B-cell level, resulting in increased CD20 +- cells. The acute phase of inflammation is characterized by an increase in CD25 +-lymphocytes, the absolute number of CD16 +-lymphocytes and apoptotic readiness CD95 +-lymphocytes. It was exposed that the functional activity of neutrophils of patients with purulent postoperative complications characterized by activation of oxygen-dependent metabolic reactions and decreased phagocytosis, indicating damage to the functions of polymorphonuclear leukocytes. Deregulation of the immune response, an imbalance in the production of Th1-Th2-Th3-cytokines were founded. These changes are associated with the progression and the further development of infections and complications. The features of Th1-Th2-Тh3- cytokine profile of lymphocytes in patients with purulent diseases of the abdominal cavity and postoperative purulent complications were investigated. Value changes of local and systemic cytokine levels in patients with purulent diseases of the abdominal cavity and significant differences in the status of cytokines depending on the bodies, which were operational intervention were founded. Markers of severity of purulent complications were clarified.