Shkurupiy D. Newborns' multiorgan failure syndrome: risk factors, genesis, increasing of diagnostic effectiveness and intensive сare

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0513U001165

Thesis Registration Form

0513U001165.pdf

Applicant for

Shkurupiy Dmytry

Specialization

14.01.30 - Анестезіологія та інтенсивна терапія

Date of defense

25-10-2013

Specialized Academic Board

Д 08.601.01

Essay

Theoretical generalization is performed and practical ways of solving the science problem - increasing of diagnostic effectiveness and intensive сare newborns' multiorgan failure syndrome - are offered in Dissertation. The choice of diagnostic criterions of this syndrome is based on the proposed conception morphological substrate. New factors which have influence on syndrome formation were found. Specialties of clinical progression are determinate. The definition method of risk of this newborns' syndrome development is developed. It is showed, that pathogenesis of newborns' multiorgan failure syndrome is realizing on different levels of biological organization. The role of expression and polymorphism of Toll-like receptors of the 2-nd type gene is showed, disturbances of cellular energizing and interferon's-alpha production. Technology of intensive therapy optimization of this syndrome by exogenic inhalational administration of interferon-alpha and infusion of natrium succinate was offered.

Thesis supervisor

Snisar V.І.
Shunko E.Е.

Official opponents

Шейман Борис Семенович
Тітов Іван Іванович
Курапов Євген Петрович

Files

akty--Акт внедрения Беларусь 1-я ГКБ.jpg

akty--Акт впровадження Кіровоградська ОЛ.jpg

akty--Акт впровадження ІФНМУ.jpg

akty--Акт впровадження Івано-Франківська ОДКЛ.jpg

akty--Акт впровадження БелМАПО.jpg

akty--Акт впровадження Дніпропетровськ 001.jpg

akty--Акт впровадження Дніпропетровська ОДКЛ.jpg

akty--Акт впровадження Кременчук МПБ.jpg

akty--Акт впровадження Полтава ДМКЛ.jpg

akty--Акт впровадження Полтава ДОКЛ.jpg

akty--Акт впровадження УМСА.jpg

akty--Акт впровадження ХМАПО.jpg

akty--Акт впровадження Харків 001.jpg

aref.doc

dis.doc

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