Vastyanov R. Pathophysiological mechanisms of the epileptic activity in case of chronic epilepsy

The thesis is devoted to the chronic epileptic activity pathophysiologic mechanisms studying. The new data received concerning chronic seizure syndrome pathophysiologic mechanisms within the kindling, postkindling, status epilepticus, posttraumatic and pilocarpine-provoked seizures. Firstly kyotorphin, neokyotorphin, d-ser-2- neokyotorphin and delta-sleep inducing peptide antiepileptic effects are established in conditions of acute and picrotoxin-kindled seizures together with peptide anticonvulsive activity correlation with its anti-ischemic action evaluation. The data obtained are pathophysiological background for experimental chronic seizure syndrome mechanisms of development studying taking into account peptide- and cytokines-induced mechanisms. Peptidergic mechanisms are estimated as pathogenetic in conditions of brain epileptization. Mutual neural and immune system interactions are identified which are responsible for general disregulatory effect formation in conditions investigated pathology. Original data showed the chronic epileptic activity systemic neuropathophysiological mechanisms and are the experimental background for chronic forms of epilepsy pathogenetic treatment methods performing out.