Meretskyy V. Pathogenesis of internal organ damage in experimental traumatic brain injury combined with streptozotocin induced diabetes

The results of research of gradual damage pathogenetic features of the internal organs in traumatic brain injury combined with streptozotocin induced diabetes have been presented in the dissertstion. The conducted studies have revealed the fundamental molecular mechanisms underlying lesions of the internal organs in conditions of brain injury on the hyperglycemia background. It has been shown that traumatic brain injury in the diabetes background is accompanied by a deepening of catabolic metabolism, increased oxidative and nitrooxidative stress, endotoxemia, deterioration of energetic metabolism in the inner organs. It has been established that in the combined pathology the degree of blood oxygenation and the intensity of tissue respiration are reduced and this fact indicates significant strain of the oxygen transport and consumption mechanisms as well as oxygen balance destabilization. Cellular immunodeficiency with decreased nonspecific reactivity, steady growth of the proinflammatory cytokines concentration, reduced level of antiinflammatory cytokines, increased intensity of granulocytes apoptosis and increased levels of reactive oxygen species in granulocytes occur in the injured animals. It has also been shown the significant tension of regulatory mechanisms with dominated sympathicotonia that positively correlated with the corticosterone serum concentration in animals with cranial injury and diabetes. These disorders correlated tightly with the structural changes in the inner organs of rats with trauma on the diabetes background.