Pisarev A. Health status of newborns from mothers with herpesvirus infection: mechanisms of immunological reactivity formation, diagnosing and correction of abnormality.

This thesis proposed the new decision of science problem consists in: theoretical generalization of findings of investigation of mechanisms and factors of intrauterine infection realization in newborns from mothers with herpesvirus infection; immunity system state determination; and thereon pathogenetic substantiation and development the system of fetus and newborn perinatal protection, which helps to reduce the neonatal morbidity and mortality. On the basis of integrated study for the first time it was established, that in woman with herpesvirus infection the fetation is occurring on mother's cellular immunity suppression background. During intrauterine infection the changes of newborn's cellular immunity are characterized by imbalance with decreasing of T-helper activity and rising of cytotoxic component share, IgM increasing, complement activity increasing, uncompleteness phagocytosis, increasing of IL-6/IL-8 proinflammatory cytokines concentration. Thereby, the majority of such newborns have immunosuppression and appropriate infection clinical signs are theoretical ground for inclusion of immunocorrective drugs to therapy complex of such children. It was justified, developed, and implemented the system of fetus and newborn perinatal protection. This system is consist: antenatal stage - intrauterine infection prophylaxis, neonatal stage - determination of lactation possibility, infection diagnosis, pathogenetic treatment, and follow-up observation up to 1 year age old - detection and treatment of infection long-term effects.