Svitlyk H. Coronary artery diseases in patients with noxious working conditions: clinical course, myocardial remodeling and development of heart failure

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0515U000021

Thesis Registration Form

0515U000021.pdf

Applicant for

Specialization

  • 14.01.11 - Кардіологія

24-12-2014

Specialized Academic Board

Д 20.601.01

Ivano-Frankivsk national medical university

Essay

The hospital period of STEMI in persons with occupational hazards (OH) was characterized by a more frequent occurrence of recurrence of MI, acute left ventricular aneurysm and thrombus formation, ventricular paroxysmal tachycardia, ventricular fibrillation, life threatening ventricular arrhythmias (LTVA), p <0.05. The central role in mechanisms of increased risk of LTVA in patients with OH had autonomic imbalance, heterogeneity of ventricular repolarization, and more frequent and longer episodes of painless myocardial ischemia. Cardiomyocytes near scars in regions of chronic aneurysms were exposed to hibernation, apoptosis, and secondary necrosis more often in persons with OH. Ventricular remodeling with systolic and diastolic dysfunction and systemic immunoinflammatory activation were more pronounced in persons with OH (р<0,0001).

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Files

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