Kostjukov V. Energetics of complexation of biologically active compounds with nucleic acids in aqueous solution

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0515U000036

Thesis Registration Form

0515U000036.pdf

Applicant for

Specialization

  • 03.00.02 - Біофізика

25-12-2014

Specialized Academic Board

Д 64.051.13

V.N. Karazin Kharkiv National University

Essay

Object of investigation: complexing a biologically active compound (BAC) and nucleic acids (NA) in the aqueous solution. Aim of work: establishing the role of various physical factors in stabilizing complexes of BAC with NC in the aqueous environment. Methods of investigation: statistical thermodynamics, nonlinear Poisson-Boltzmann equation, molecular dynamics, quantum chemical methods. Scientific novelty: this thesis presents a systematic implementation of the new strategy of the energy analysis of the reactions of formation of complexes of BAC and NC in aqueous solution based on the decomposition of the total Gibbs energy of complexation reactions into contributions from individual physical factors. Practical meaning: application in molecular biophysics, molecular biology and biotechnology.

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Files

aref.doc

dis.doc--ВВЕДЕНИЕ.doc

dis.doc--ВЫВОДЫ.doc

dis.doc--Приложение А.doc

dis.doc--Приложение Б.doc

dis.doc--Приложение В.doc

dis.doc--Раздел 1.doc

dis.doc--Раздел 2.doc

dis.doc--Раздел 3.doc

dis.doc--Раздел 4.doc

dis.doc--Раздел 5.doc

dis.doc--Раздел 6.doc

dis.doc--Раздел 7.doc

dis.doc--Раздел 8.doc

dis.doc--СОДЕРЖАНИЕ.doc

dis.doc--СПИСОК ИСПОЛЬЗОВАННЫХ ИСТОЧНИКОВ.doc

dis.doc--СПИСОК УСЛОВНЫХ ОБОЗНАЧЕНИЙ.doc

dis.doc--Титульный.doc

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