The object of study - the state policy in the field of public health. The purpose of research - development of theoretical and methodological foundations, scientific and methodological approaches for the development of mechanisms of state control in the sphere of public health of Ukraine. Research methods - logical generalization, synthesis, analysis, comparison, systemic, structural and functional studies, forecasting, positioning matrix. The practical significance of these results is that the studies' position as a scientific and methodological generalizations and practical recommendations are used in the practice of local authorities and local self-government, heads of medical institutions, the learning process in the preparation of specialists in "Management in Health Care". Scientific novelty of the research lies in the fact that the first place and role of the citizen and the state allocated in the Ukrainian society, the citizen is defined not only as an object, but also as the subject of state policy in the field of health, the principles of financial and economic restructuring of the health system justified in view of the main principle Tallinn Charter "health Systems for Health and well-being" called "health in all policies", the main directions of development of mechanisms of governance in the health sector in the context of international experience offered. The main functions of the structure, organization provides strategic management of the health system, the concept of multi-channel optimization of government funding of Health due to the introduction of compulsory health insurance and a mixed system of filling insurance fund, scientific and methodical approach to the modernization of the personnel policy of the state in the management of health care, the essence of which is to restructuring of management performance and reform in accordance with the new needs of society, improved. The definition of "system" in health care, concept and content of public administration in the health sector, as well as its special characteristics, the direction of the impact of several factors on the choice of research methodology, recommendations for priority legislative solutions to improve the process of municipal management in the health sector, an integrated approach to improve the quality of care, as well as ways of its assessment, scientific and methodical approach to the assessment of the health system were further developed.