Karlova E. The markers of development of homeostasis disorders and the stratification of prognosis of the risk level of complications at microsaturnism

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0515U000289

Applicant for

Specialization

  • 14.02.01 - Гігієна

16-04-2015

Specialized Academic Board

Д 26.003.01

Essay

The dissertation is devoted the studying of the actual problem of preventive medicine for early diagnosis microsaturnism. The work examines the effects of lead on the formation of professional risk on the health of employees who professionally contact with lead. Determined early preclinical markers of the violation homeostatic functions, including the immune system. The features of formation of endothelial dysfunction, vascular immunoinflammatory response and structural changes in the internal organs in the professional lead exposure were studied. The pathogenetic mechanisms of formation of intoxication by lead were substantially supplemented by a study of mechanisms of occurrence and formation of the toxemia. New approaches have been developed and recommended for early diagnosis of homeostatic functions of workers who exposed by lead, and allow determine the individual risk of the development of microsaturnism and make timely the proposed set of preventive health - improving measures that aimed at preserving the health of workers.

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