Kotyuzhinska S. Pathophysiology of lipid transport system and its role in atherosclerosis’ pathogenesis

The thesis presents the solution of scientific problems of the pathogenesis of atherosclerosis functional state of lipid transport system in the conditions of hypo- and hyperheparinaemia status of people and animals. For the first time it has been studied, that pathological mechanisms of disturbance of fat's transport on the level of tissues, where mast cells - heparin - lipoprotein lipase take part. For the first time it has been established, that level of heparinaemia determinates as character of changes of lipoprotein lipase's activity, as particularities of rebuilding of lipid transport system's functions as a whole. Lipoprotein lipase's quantitative and qualitative indeces of function change in the condition of heparin's low concentration in blood's plasma, that leeds to development of dyslipidemia, disturbance of utilization of fatty acids, which are shown, as the increase of concentration of saturated fatty acids on the background of the decrease of ?-3 unsaturated fatty acids 'level. It is shown, that the disturbances of lipid transport system have as antiatherogenic character, as proatherogenic inclination in the conditions of pathological states with hyperheparinaemia's appearances. It has been established, that the oppression of lipoprotein lipase is one of the important mechanisms of lipoproteins 'metabolism and disturbances of lipid transport system in the condition of the decrease of tissues "functional necessities. This can be occurred in the condition of the decrease of lipoprotein lipase's activity, that is made by hypoheparinaemia, which occurs as a result of the depletion of mast cells.