Ilyina T. Pharmacognostic study of family Rubiaceae species and prospects of their applications in medicine

The thesis presented is aimed at resolving the problem of a systemic target research in raw sources of biologically active substances (BAS) of the family Rubiaceae Juss., and development, on their basis, of medicinal drugs. A comprehensive pharmacognostic study of the chemical composition of 15 species of the genera Galium L., Asperula L. and Cruciata Mill., including the standardization of the raw materials, was carried out. The results of morphology-taxonomic and chemo-taxonomic study of the species of the genera Galium L., Asperula L. and Cruciata Mill. enabled to resolve certain disputable issues in the systematization of the given genera and elaborate a theoretical model for prospecting relevant BAS sources on the basis correlation between the presents of flavonoids and morphological features of the given species. Developed is a technology for the preparation of lipophilic and phenolic complexes and dry extracts from the herbs of 11 species of the given genera, their chemical composition and pharmacologic effects established and standardization parameters researched. Proposed are the drafts for the quality control procedure for the raw material and dry extracts under study. On the basis of the results obtained in standardization of Madder rhizomes and roots, the project of the national SPU monograph "Rubiae Rhizomata et Radices" was completed.