Makarenko M. Place and role of fetoplacental system in development of syndrome a growth inhibition of fetus.

The work is devoted to the development of new approaches to the diagnosis, prevention, treatment and prediction of syndrome a growth inhibition of fetus (SGIF), given the theoretical foundations and created a new direction of research state on the fetoplacental subsystem in this pathology. Identified by morphological, morphometric, ultrasound, immunological, genetic and other criteria pathology components, with the development of pathology in the fetoplacental complex and relevant to early preclinical diagnosis of SGIF. Determined by differential diagnostic criteria and the concept of the pathogenesis of various forms of SGIF, developed modern obstetric tactics and correction of these disorders in order to reduce perinatal morbidity and mortality. It is shown that the SGIF develops against the background of hemodynamic instability in the mother-placenta-fetus, the severity of which may be assessed by comparing changes in the spiral flow, the uterine arteries, the main blood vessels of the umbilical cord, and fetus. Conducted a comprehensive study of the state of fetoplacental complex has allowed to formulate a new scientific concept, which explains pathological and pathophysiological changes in the SGIF and allows you to develop criteria for predicting the course of pregnancy and childbirth in this pathology. It is proved, that the effectiveness of therapy depends on the degree, forms SGIF, gestational age, and requires differentiated tactics of treatment. System diagnosis, prevention and differentiated treatment and management of pregnant women with SGIF, which proposed will reduce the frequency of obstetric and perinatal complications and improve perinatal morbidity and mortality of newborns.