Kresiun N. Pathogenetic basis of the brain structures activation methods in the complex treatment of diabetic retinopathy (experimental and clinical investigation)

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0516U000251

Thesis Registration Form

0516U000251.pdf

Applicant for

Specialization

  • 14.03.04 - Патологічна фізіологія

24-03-2016

Specialized Academic Board

Д 17.600.04

Zaporizhzhya State Medical University

Essay

The main pathogenetic mechanisms of the development of diabetic retinopathy (DR), which encompass the activation of all components of oxidative stress, suppression of antioxidative defence, intensification of nitrosative stress, increasing of the vascular endothelial growth factor level, changes of electroretinographic characteristics in a form of latent period prolongation along with the reduction of evoked potentials amplitude, degenartive deteriorations - increasing the number of both acellular capillars and pericytes ghosts, reduction of the number of neurons in the outer and inner nuclear as well as in ganglionar layers of retina have been revealed and based on the model of streptozotocin-induced diabetes in rats. It was approved that combined usage of electrical stimulation of paleocerebellar cortex together with the pharmacological agent "deltalicin", which is based on delta sleep-inducing peptide, and anti-VEGF pharmacon "lucentis" resulted in potentiated therapeutic effect. The analogous data have been got from patient treatment who suffered from DR with different stage of severity. The high sensitivity and specificity of the early diagnostics of both microaneurism appearance and retinal pigment loss as markers of DR development, have been shown and introduced into clinician practice.

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