Matvieieva N. Construction of plants - producers of biologically active compounds by Agrobacterium-mediated transformation

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0516U000259

Thesis Registration Form

0516U000259.pdf

Applicant for

Matvieieva Nadiia Anatoliivna

Specialization

03.00.20 - Біотехнологія

Date of defense

29-03-2016

Specialized Academic Board

Д 26.254.01

Institute of Food Biotechnology and Genomics of the National Academy of Sciences of Ukraine

Essay

The thesis is devoted to the development of efficient method of transformation of Cichorium intуbus L., Lactuca sativa L., Althaea officinalis L., Tragopogon porrifolius L., Lemna minor L., Artemisia tilesii Ledeb, Bidens pilosa L. and Ruta graveolens L. plants with human ifn-?2b or Mycobacterium tuberculosis esxA-fbpB genes using Agrobacterium tumefaciens or A. rhizogenes. An ability to synthesize natural biologically active compounds (artemisinin, fructans) and recombinant proteins (human interferon-alfa2b and Mycobacterium tuberculosis ESAT6-Ag85B antigens) has been demonstrated in biotechnology plants and "hairy" roots. Extracts of transgenic lines demonstrated UV-protective, antimicrobial, antioxidant, antiviral activities.

Thesis supervisor

Kuchuk Mykola Viktorovych

Official opponents

робик Надія Михайлівна
Тищенко Олена Миколаївна
Косаківська Ірина Василівна

Files

aref.doc

Матвєєва дисертація.pdf

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