Kyselov S. Myocardial infarction, complicated by left ventricular aneurysm: clinical, structural and functional peculiarities of the course, diagnostic, therapeutic and prognostic aspects

The dissertation presents a new solution for the problem of modern cardiology to improve the efficiency of diagnosis, treatment and prognosis of Q-wave myocardial infarction complicated by acute aneurysm and thrombus of left ventricle. The peculiarities of clinic, heart rhythm variability, diurnal blood pressure profile, early postinfarction remodeling and diastolic heart function, activity of processes of systemic inflammation, extracellular matrix degradation, coagulation and thrombocyte aggregation were revealed in patients with Q-wave myocardial infarction complicated by formation of acute aneurysm and thrombus of left ventricle. There were identified independent predictors of acute left ventricular aneurysm, acute aneurysm with left ventricular thrombus, hospital mortality and mortality of patients within a year after the acute Q-wave myocardial infarction. It was proven that thrombolytic therapy applied after two hours from the onset of myocardial infarction, administration of high doses of statins, the selective aldosterone antagonist, the beta-blocker reduce the relative risk of left ventricle aneurysm with thrombus formation, hospital mortality and mortality of patients within a year after the acute Q-wave myocardial infarction