Kalmykov O. Mechanisms of realization of cardiorespiratory disturbances in occupational diseases of bronchopulmonary system with accompanying coronary artery disease: diagnosic and prophylactic aspects.

Clinico-pathogenetic grounding of the concept of improvement of methods of prophylaxis and diagnosis of chronic occupational diseases of bronchopulmonary system (chronic bronchitis, chronic obstructive pulmonary disease, pneumoconioses, bronchial asthma) in combination with chronic cardiovascular pathology (coronary artery disease: stable stenocardia of effort of 1st-2nd functional class, post-infarction and diffuse cardiosclerosis; systemic arterial hypertension) is represented in the dissertation in the aspects of clinico-genetical, clinico-hygienic, psychosocial, hemodynamic, immunoinflammatory changes, endothelial dysfunction, disturbances of oxidative homeostasis.As factors of endogenic predisposition to the development of separate pathogenetical changes in conditions of cardiorespiratory pathology at first time in Ukrainian population the concrete unfavourable genetic alleles have been distinguished, associated with remodeling of bronchial-alveolar and interstitial pulmonary architectonics, initiation of hypersensitivity reactions and further moderation of immune response by specific or non-specific patterns, disturbances in regulation of vascular tone and dysfunction of vessels endothelium, vasoconstriction and atherogenesis. The clinico-pathogenetic expedience of genetic oligolucleotid polymorphism of surfactant, immunoinflammatory, endothelial, cardiovascular issues of homeosthasis study in patients with cardiopulmonary pathology has been grounded. In the aspect of the role of exogenic factors (working conditions and peculiarities of work process, life style) the threshold values of concentrations of industrial aerosol in and air of work zone, parameters of exposition of causative and associated factors, and also association with intensity of smoking have beed elaborated. Pathogenetic factors which play a determinative role in terms, evidence, type and character of course of cardiac dysfunction have been defined. The place of cytokines dysbalance with taking into account of interleukines 17 and 33 associated status resulting in definite respiratory phenotype and cause different degree and character of involvement of myocardium and functional heart decompensation has been studied.