Sydorenko L. Synthesis, physicochemical properties and the biological activity of 4-R-2-oxo-1,2-dihydroquinoline-3-carboxylic acids and their derivatives

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0517U000271

Thesis Registration Form

0517U000271.pdf

Applicant for

Specialization

  • 15.00.02 - Фармацевтична хімія та фармакогнозія

05-04-2017

Specialized Academic Board

Д 64.605.01

National University of Pharmacy

Essay

The thesis is devoted to development of a new scientific direction in the synthesis of new biologically active compounds of quinoline series based on the transformation of esters of 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acids involving almost all functional groups in the chemical transformation. The antitubercular, diuretic, anti-inflammatory activity of the compounds synthesized, as well as the ability to block opioid receptors have been studied. The original compound Nalquilone – synthetic antagonists of opioid receptors of a new chemical class has been found; the project for Drug Quality Control Methods and provisional regulations for manufacturing process have been developed for it.

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Files

dis.doc

Автореферат-Сидоренко-Л.В..pdf

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