Andrii L. Early diagnosis and prediction of kidney injury in newborns with asphyxia

The thesis is devoted to creating conceptual approach to early diagnosis and prognosis of renal injury in newborns with asphyxia by identifying clinical risks, levels of modern biomarkers, crystallographic changes, enzyme and cytokine profiles, exposure of toxic microelements and violation of essential elements balance. Clinical and anamnestic risk of renal damage in full-term newborns are fetal distress, respiratory disturbances, Apgar scores at 1 and 5 minutes. Early non-invasive markers of kidney injury should be considered content in urine IL-18> 25 pg/ml, GGTP> 47 nmol/(s * l) and Ca> 0.8 mmol/l. The main risk factors of kidney damage are increase serum level of Cystatin C> 2600 ng/ml, NSE> 56.2 ng/ml, TNF? > 8.5 pg/ml, IL-10> 10 pg/ml, GGTP> 120 nmol/(s* l) and Pb> 0,200 mmol/l. Intensive care of newborns with asphyxia should be based on nephroprotective principles. For early diagnosis of kidney damage with violation of their function in neonates with asphyxia appropriate to apply the proposed multi-marker system of consistent prognosis.