Gavrilyuk A. Mechanisms of formation of immune-dependent infertility in individuals of male gender with organ-specific and systemic autoimmune diseases

Aim of the work was to investigation the immune-dependent mechanisms of infertility in boys, men and animals with autoimmune and other accompanying diseases in experiment and clinical practice. We conducted modeling of the systemic disease of the connective tissue (collagen-induced arthritis) in experiments in male rats. We found that activation of the synthesis of active radicals of oxygen and nitrogen plays one of the key roles in the pathogenesis of the experimental collagen-induced arthritis, in which testicles and epididymis get damaged. Death of germinal cells occurs through the mechanism of apoptosis with the envolvement of the system Fas-FasL, induced system of cytokines, that are closely associated with oxidative and nitrosative stress. We showed that morphologic examination of the tissue of testicles and epididymis and immune-histochemical determination of the markers of apoptosis FasLand caspase-3 are the most evident confirmation of the diagnosis of primary and secondary orchitis.