Pakholchuk O. Differential approach to the diagnostics, treatment and prophylaxis of the food hypersensitivity in children

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0519U000266

Thesis Registration Form

0519U000266.pdf

Applicant for

Specialization

  • 14.01.10 - Педіатрія

17-04-2019

Specialized Academic Board

Д 17.600.02

Zaporizhzhya State Medical University

Essay

The dissertation presents a solution for the problem of modern pediatrics – improvement of diagnostics, treatment and prophylaxis of the food hypersensitivity (FH) in children with scientific prove of the differential diagnostics based on the studying of the risk factors, pathogenetical mechanisms and features of the course. There were peculiarities of the mucosal and epidermal barrier functioning, activation of the factors of gene transcription (JAK-STAT) estimated. Prevalence of the FLG gene mutations and polymorphism of the SPINK5 gene in children with FH was assessed. Phenotypes of FH and steps of diagnostics were proposed. It was proved that effectiveness of the proposed treatment results in the less frequency and duration of the exacerbations and depends on results of the skin prick-test, level of IL-2 and TLR-4 in serum, lactulose in urine.

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Files

autoreferat--Пахольчук О.П._Автореферат.pdf

Пахольчук О.П._Дисертація.pdf

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