Ivanchenko D. Synthesis, reactions, physicochemical and biological properties of N- and C8-substituted and condensed xanthine derivatives

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0519U001588

Thesis Registration Form

0519U001588.pdf

Applicant for

Specialization

  • 15.00.02 - Фармацевтична хімія та фармакогнозія

03-10-2019

Specialized Academic Board

Д 17.600.03

Zaporizhzhya State Medical University

Essay

The dissertation is devoted to the search for biologically active compounds among the N- and C8-substituted and condensed xanthine derivatives. Methods for obtaining 8-aminoxanthines by the reaction of 8-bromo-xanthines with benzylamine, amino alcohols, secondary heterocyclic amines were studied. Acute, chronic toxicity, specific activity of 1-[7-(2-hydroxyethyl-1)-3-methylxanthin-8-yl]piperazine chloride, which, according to biological screening, exhibits hypotensive activity, were studied. A tablet dosage form technology was developed, and proposed project of quality control methods for the substance and dosage form «Oxypiperoxane».

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