Tsybulska T. Functional, biometric and biomechanical changes in eye parameters during myopia in children: features of treatment and optical correction

The dissertation is dedicated to solving the urgent scientific and applied problem of modern ophthalmology - improving the effectiveness of treatment and optical correction in children with acquired myopia based on a comprehensive study of functional, biometric, biomechanical changes in eye parameters and biochemical features of connective tissue metabolism with subsequent pathogenetically substantiated correction of the revealed disorders. It was established that changes in the functional, biometric, biomechanical parameters of the visual analyzer, biochemical indicators of connective tissue metabolism represent a single complex of pathogenetic changes during the development and progression of acquired myopia in children. The quantitative ophthalmological criteria of the visual analyzer are determined, which allow discrimination in acquired myopia between the presence of undifferentiated connective tissue dysplasia syndrome and its absence. Mathematical modeling obtained a set of predictors that determine the development and progression of acquired myopia in children, which include individual anatomical and optical parameters of the eye, accommodation status, anamnestic data, stigma of connective tissue dysplasia, and their quantitative indicators are established. Clinical and biochemical studies revealed pathological features in the pathogenesis of acquired myopia, which include a decrease in the level of magnesium and calcium electrolytes, an increase in hydroxyproline in daily urine, and relationships were established between changes in these biochemical parameters with parameters of the visual analyzer with progressive acquired myopia. It is proved that progressive myopia requires an assessment of the general condition of the child's body. The necessity of complete optical correction of myopic refraction, the advantages of orthokeratological optical correction, as well as the need for local and general metabolic therapy in the complex treatment of progressive myopia in children are substantiated.