Kal'bus O. Clinical and pathogenetic characteristics and prognosis of myasthenia gravis.

The dissertation presents a theoretical generalization and a new scientific and practical solution to the problem of early diagnosis and prognosis of myasthenia gravis, based on data from a comprehensive clinical, epidemiological, immunological, biochemical, neuropsychological study, which allowed to develop a prognostic model of myasthenia gravis. Medical and statistical, clinical and epidemiological characteristics of the prevalence of myasthenia gravis in the regions of Ukraine have been determined. The role of clinical and immunological factors has been clarified, as well as the role of oxidative stress in the development and progression of myasthenia gravis. The structure of comorbidity in myasthenia gravis was studied. Clarification of gender and age aspects of the onset of myasthenia gravis. Features of psycho-emotional changes in patients with myasthenia gravis, as well as factors influencing their development have been identified. Predictors of low survival and mortality in myasthenia gravis have been established.