Psaryova V. Molecular genetic and neurohumoral mechanisms of cardiovascular remodeling and their correction in patients with essential hypertension with concomitant obesity.

The object of study: comorbid pathology - essential hypertension with concomitant obesity. The aim of the study is to improve the quality of diagnosis and effectiveness of treatment of essential hypertension and its connections with metabolic disorders in obese patients based on the study of the features of differentiated integration of molecular genetic, neurohumoral and environmental factors and their dynamics under the influence of pathogenetically sound therapy. Research methods: Clinical – anamnestic; anthropometric; biochemical; automated methods of immune analysis; spectrophotometric; molecular genetic methods; instrumental; statistic. In scientific work, based on the analysis of the results of the examination of 340 patients with AH with different body weight and different types of metabolic comorbidity obtained the data, based on which the prevalence of favorable and unfavorable genotypes based on G972R polymorphism of IRS-1 gene and G276T polymorphism of ADIPOQ gene was first established in patients with AH depending on body weight and type of comorbidity. It is determined that the prevalence of unfavorable genotypes for G972R polymorphism of the IRS-1 gene and the G276T polymorphism of the ADIPOQ gene in patients with AH and obesity was determined to be 45% and 62%. Physical activity has been proven to be an important factor in improving the dynamics of treatment in patients with AH with obesity in different drug therapy regimens. For the first time, combinations of genetic and neurohumoral factors that influence the development of AH resistance to treatment have been studied, the main determinants of the formation of true and pseudoresistant AH have been identified.