Popadyuk O. Innovative technologies in surgical treatment of soft tissue wounds and prevention of their complications (clinical and experimental study)

The dissertation is devoted to improvement of results of treatment of purulent wounds by development of a new method of treatment on the basis of nanoscale biodegradable polymeric materials. Biodegradable polymeric material for the treatment of purulent wounds has been developed, its physicochemical and mechanical properties have been studied in vitro, tested in in vivo experiments on animals in the modeling of cut, plane and burn wounds complicated by purulent infection and the possibility of using the developed polymers in surgical organs was investigated the cavity. The antimicrobial properties of nanosized metal particles were studied and the mechanism of their action was substantiated. The efficiency of the use of the developed polymers in the surgery of wounds of different genesis depending on the phases of the wound process is proved. The use in the clinic of biodegradable polymer film "biodep-nano" as an aid in the prevention of secondary infection in surgical wounds and burns of stage I and II is justified, highly effective and modern. The developed method of treatment of purulent wounds based on the use of nano-containing polymeric materials allows to improve the treatment of purulent wounds, reduce wound healing time, and the developed polymeric material is the basis for the development and improvement of new generation wound healing materials. A developed method for the treatment of purulent wounds based on the use of nanoscale polymeric materials allows to improve the treatment of purulent wounds, reduce the time of wound healing, and the developed polymeric material is the basis for the development and improvement of materials for the healing of new generation wounds.