Kozub M. Restoring the reproductive health of women who have undergone tubal pregnancy surgery: a clinical and experimental study.

The dissertation is devoted to improving the effectiveness of reproductive health in women with tubal pregnancy after its laparoscopic treatment. The effects of different types of surgical energies, anti-adhesion barriers, biotechnological drug and assisted reproductive technologies on fertility restoration of the above mentioned patients were experimentally and clinically identified. To achieve the goals and objectives set in the dissertation, we modeled the operated fallopian tube, adhesion process that occurs under the influence of diathermic, radio wave energies and scalpel incision in 196 Wistar rats' females. It was determined that use of radio wave energy for female rats oviducts opening and anti-adhesion barrier PEO with CMC use together with a biotechnological drug led to the development of the 1st stage adhesion process in 35.7% of rats, which was 1.2 times less compared to the isolated use of PEO with CMC. A complete restoration of the oviduct walls' morphological structure in experimental rats was observed. The number of fetuses in female rats of this group did not differ (p>0.05) from the corresponding indicators in the control group of animals. For pathogenetical substantiation of biotechnological placental drug use in the treatment of patients with tubal pregnancy, we also conducted experimental studies on 90 mice of the BALB/c-line to study the effectiveness of biotechnological drug aimed at restoring the morphological and functional state of reproductive organs. Based on the study, it was determined that biotechnological drug use in mice with a model of premature ovarian failure contributes to the restoration of morphological structure of the uterus, partial restoration of ovarian structure with the appearance of follicle-like structures in 4 weeks, in 5 weeks - restoration of sexual function in 70% of mice and in 8 weeks - restoration of generative function in 80% of mice.