Object of research: processes of vital activity of territorial communities in cross-border space. Purpose: substantiation of theoretical and methodological principles of socio-economic development of territorial communities in the cross-border space and development of scientific and practical recommendations for the organization of life of territorial communities in terms of intensification of cross-border cooperation. Methods: monographic, economic and statistical, logical generalization, analysis, comparison and synthesis, comparisons, sociological research, analysis and synthesis, strategic and structural-functional analysis, graphical visualization, scientific generalizations. Novelty: for the first time a methodological approach to the study of territorial communities in cross-border space was formulated, organizational and economic bases of territorial community development in cross-border space were substantiated on the basis of asset-oriented approach, conceptual approach to behavior of cross-border markets was proposed; methodological approach to the study of the impact of cross-border factors (opening and operation of checkpoints across the state border; introduction of mutual simplifications when crossing the border by residents of border areas; functioning of cross-border markets) on the development of border communities, classification of interaction between participants and participants. features, methodological approach to comprehensive monitoring of cross-border cooperation, conceptual and categorical apparatus of cross-border cooperation on the definition of "cross-border association" as a voluntary association of subjects and / or participants of cross-border cooperation of Ukraine and neighboring countries provided for in the cross-border cooperation agreement were improved. Scope of application: in the activities of the Committee on Integration of the Verkhovna Rada of Ukraine in drafting the law №6085, which is part of the package of European integration laws, the Directorate for Local Government Development, Territorial Organization of Government and Administrative and Territorial Organization of the Ministry of Community Development communal property of territorial communities, the Association of Local Self-Government Bodies "Euroregion Carpathians - Ukraine" for the formation and implementation of a joint strategy of smart specialization of regions within Euroregions, the Ministry of Regional Development, Construction and Housing of Ukraine to build local civil society in the context of territorial communities , Ministry of Social Policy in the formation of policy in the field of cross-border cooperation, the Department of Foreign Economic Activity and European Integration of the Odessa Regional State Administration during the preparations and planning of measures to intensify cross-border and interregional cooperation, the standing commission of the Drohobych City Council on planning, budget, finance, pricing and investment in the preparation of recommendations and proposals for the council session.