Regeda-Furdychko M. Pathogenetic justification for the use of thiotriazoline in the development of contact dermatitis and experimental pneumonia

Українська версія

Thesis for the degree of Doctor of Science (DSc)

State registration number

0521U100990

Thesis Registration Form

0521U100990.pdf

Applicant for

Specialization

  • 14.03.04 - Патологічна фізіологія

23-04-2021

Specialized Academic Board

Д 58.601.01

Ternopil National Medical University named after I. Gorbachevsky of the Ministry of Health of Ukraine

Essay

Manifestation of contact dermatitis in the combination with pneumonia is accompanied by the suppression of cellular immunity, the reduction of phagocytic leukocyte activity, IL-10, L-arginine, indicators of antiprotease and antioxidant systems on the background of the elevation markers of humoral immunity, pro-inflammatory cytokines, proteolytic and oxidative processes, stable metabolites of nitric oxide, total nitric oxide synthase activity and endotoxication in the blood, skin and lungs, which prevailed on the 8th and 10th days, and, especially, on the 18th day of these experimental models of diseases in the relation to the intact group of animals. Antioxidant and immunomodulatory correction of impaired metabolic and immune systems in the formation of contact dermatitis and experimental pneumonia have been pathogenetically justified.

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Files

autoreferat-Автореферат_Регеди-Фурдичко_М_М.docx

Дисертація Регеди-Фурдичко_М_М.docx

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