Cheren'ko S. Diagnosis, trends of pathomorphosis and morbidity, prognosis of development and surgical treatment of focal pathology of thyroid gland

Рatients with focal thyroid pathology (FTP) - nodular goiter, benign and malignant tumours, cysts, thyroidites. To increase efficacy of diagnosis and treatment of patients with FTP by working out of diagnostic algorhythm and treatment technology on the basement of pathogenetically determinated surgical and minimally-invasive methods. Methods of investigations: statistic, clinical, ultrasound, radiologic, roentgenologic, radioimmunologic, morphologic, neuroelectrophysiologic (EEG, rheoencephalography, auditory evoked potentials with analysing system MK-6 "Amplaid"), local mass-spectrometry with the laser mass-spectrometer. Common trends of epidemiologic rates and pathomorphosis of FTP in Ukraine and Kiev city have been established, as well as some unknown factors of pathogenesis of FTP. The scheme of diagnostic-curative algorithm was created. The individualizative approach to management tactics in patients with FTP, based on the criteria of differential diagnosis and prognosis, was proposed. Patentof Uk raine to new method of prognosis of efficacy of suppressive treatment of nontoxic goiter was received. Technology of treatment of FTP, including conservative therapy, new minimally-invasive surgical procedures (patent of Ukraine to method of treatment of thyroid cysts was received) and improved methods of surgical operation, was worked out. Such approach has allowed achievement of lower rates of operative complications, the therapeutical effect by the more easy and safe way, rejection of the necessity of surgical intervention in 40 % of patients with FTP. The main results of the study have found their application in the field of practical surgery and endocrinology