Bielikova Y. Disorders of amino acid metabolism and cardiac rhythm in patients with post-infarction cardiosclerosis with concomitant type 2 diabetes mellitus, the possibility of drug correction

The thesis is devoted to solving urgent problems of internal medicine - elucidation of the pathogenetic mechanisms of electrical instability of the myocardium in postinfarction cardiosclerosis (PICS) combined with type 2 diabetes mellitus (T2DM), and optimization of the treatment of cardiac arrhythmias based on the study of blood serum amino acids, daily ECG monitoring, heart rate variability, ischemic changes in the myocardium and the choice of metabolic therapy in patients with postinfarction cardiosclerosis and concomitant type 2 diabetes mellitus. The purpose and objectives of the study. Optimization of the treatment of cardiac arrhythmias based on the study of blood serum amino acids and the choice of metabolic therapy in patients with postinfarction cardiosclerosis and concomitant type 2 diabetes mellitus. To achieve the goal, the following tasks were set: 1) To study the composition of cardiac arrhythmias in patients with postinfarction cardiosclerosis and concomitant type 2 diabetes mellitus and in persons with postinfarction cardiosclerosis without disturbances in carbohydrate metabolism. 2) To investigate the imbalance of blood serum amino acids in patients with postinfarction cardiosclerosis and type 2 diabetes mellitus. 3) To analyze the relationship of blood serum amino acids with cardiac arrhythmias. 4) Determine the diagnostic value of individual amino acids and their ratios as predictors of electrical myocardial instability 5) To assess the effect of the use of taurine and meldonia, additional to the basic therapy, for cardiac arrhythmias and the predictive value of blood serum amino acids as predictors of a positive response to treatment in patients with postinfarction cardiosclerosis with concomitant type 2 diabetes mellitus 6) To analyze additional, other from antiarrhythmic, effects of adding taurine and meldonium to basic therapy, the effect on the parameters of carbohydrate and lipid metabolism. Research object: PICS against the background of type 2 diabetes. Subject of research: PICS, type 2 diabetes, the state of amino acid, lipid and carbohydrate metabolism, indicators of ectopic activity, myocardial ischemia, spectral and temporal indicators of heart rate variability. Research methods: general clinical, clinical and laboratory (characteristics of amino acid metabolism, carbohydrate, lipid profile), Holter daily ECG monitoring, statistical analysis of the data obtained.