The total result of the research contains a rational approach to solving the problem of modification risk factors for arterial hypertension (AH) using intravenous laser therapy (IVLT). The relationship between uric acid levels (UA) and indicators of arterial wall stiffness, endothelial dysfunction, systolodiastolic function of the left ventricular myocardium, changes in erythrocyte morphology and the degree of hypertension was studied. An increase in the relative risks of hypertension in the presence of hyperuricemia (HU) has been established. A method for correcting blood pressure, uric acid level, endothelial dysfunction, arterial wall stiffness, systolodiastolic function of the left ventricular, poikilocytosis has been developed, which involves the use of IVLT with a laser power of 1.5 mW, a wavelength λ = 635 of 15 minutes every day, in combination with standard antihypertensive therapy (AHT). The effectiveness of IVLT for the correction of disorders of blood pressure (BP) disturbances at patients with essential hypertension of the I stage, 1-2 degrees was justified.
The aim of the study is to optimize the combination therapy of modifying risk factors in patients with stage I arterial hypertension using intravenous laser therapy based on the study of hyperuricemia, endothelial dysfunction and myocardial systolodiastolic function, pulse and pulse wave velocity.
Tasks of the work:
1. Analyze the data of modern multicenter randomized trials on the prevalence of guperuricemia, hypertension and their association.
2. To investigate and conduct a comparative characterization of uric acid levels, functional status of the endothelium, myocardium, pulse wave velocity, poikilocytosis in patients with stage I hypertension relative to the control group.
3. To determine the association between hyperuricemia and the functional state of the endothelium and myocardium, the rate of propagation of the pulse wave in the aorta and the level of poikilocytosis in patients with stage I hypertension, grade 1-2.
4. To analyze the relative risks of hypertension, endothelial dysfunction, systolodiastolic dysfunction of the left ventricle (LV), increased stiffness of the arterial wall, the occurrence of poikilocytosis in normotensive patients with GU in relation to normotensive patients.
5. To determine the effectiveness of intravenous laser therapy as a method of correction of the blood pressure, hyperuricemia, endothelial and myocardial dysfunction, pulse wave velocity and poikilocytosis, in the complex treatment of patients with stage I hypertension compared with standard antihypertensive therapy.
6. To establish the possibility of correction of risk factors for hypertension (ED, EDVD, Tei index, poikilocytosis, hyperuricemia) with intravenous laser therapy in normotensive individuals with HU.
The object of study is the risk factors for hypertension that can be modified.
The subject of the research - the effect of intravenous laser therapy on the level of blood pressure, uric acid, arterial wall stiffness, endothelial and systolic-diastolic function of the left ventricular, the formation of pathologically altered forms of erythrocytes.
