Kuzmina A. Algorithm for managing women with intrauterine fluid in the postmenopausal period

The dissertation is devoted to the study of the peculiarities of the origin, course, treatment and prevention of intrauterine fluid in postmenopausal patients and to the improvement of the algorithm for managing women with intrauterine fluid in the postmenopausal period. Postmenopausal women with intrauterine fluid are at high risk for both benign and malignant uterine diseases. Therefore, the development of new methods for the diagnosis of intrauterine fluid is not only an important aspect of modern medical science, but also a guarantee of prevention and early diagnosis of such a serious complication as malignant pathology of the endometrium. The aim of this work is to develop an algorithm for managing postmenopausal patients with intrauterine fluid and on the basis of functional, microbiological and pathomorphological diagnostic methods to improve differential pathogenetic treatment. Objectives of the researh: 1. To establish the frequency of intrauterine fluid in postmenopausal patients. 2. To study the clinical features of obstetric and gynecological history in postmenopausal women with intrauterine fluid. 3. To study the pathomorphological and microbiological features of the aspirate from the uterine cavity and the peculiarities of the vaginal microbiocenosis in postmenopausal women with intrauterine fluid. 4. To study the informativeness of the use of ultrasound diagnostics and Doppler examination in patients of postmenopausal period with intrauterine fluid. 5. To study the informativeness of the use of compression sonoelastography in patients of postmenopausal period with intrauterine fluid. 6. To evaluate the effectiveness of the method and the clinical significance of the combination of TVUZD with Doppler and compression sonoelastography for the differential diagnosis of pathological processes of the endometrium in the studied patients with intrauterine fluid. 7. To evaluate the effectiveness of antirelapse therapy in the complex treatment of postmenopausal patients with intrauterine fluid. 8. To develop a diagnostic and therapeutic algorithm taking into account the possibilities of ultrasound, Doppler examination, compression sonoelastography, microbiological status and data of pathomorphological examination in patients of postmenopausal period with intrauterine fluid.