Regeda S. The role of disorders of metabolic and immune processes in the pathogenesis of parodontitis in the conditions of experimental pneumonia and their correction by thiotriazoline.

The thesis is devoted to the study of the peculiarities of indicators disturbances of cellular and humoral units of the immune system, the titer of the main classes of immunoglobulins, cytokines, processes of oxidant and antioxidant systems, proteolysis and antiprotease potential in the blood and lungs in the dynamic (4 th , 8 th , 10 th and 18th days) of the experimental pneumonia and parodontitis development before and after correction by the drug thiotriazoline. Experimental studies were conducted on 140 guinea pigs (males) weighing 0.18-0.21 kg, who were kept on a standard vivarium diet of Danylo Halytsky Lviv National Medical University. It was first established that the inflammatory process in the lungs and tissues of the parodontal complex is accompanied by the activation of lipid peroxidation processes with excessive accumulation of their products on the background the suppression of the antioxidant protection enzymes activity – superoxide dismutase, catalase and glutathione peroxidase in the lungs from 8th and particularly on the 18th day of the experiment. It has been shown for the first time that experimental pneumonia combined with parodontitis leads to the suppression of cellular link on the background of the stimulation of humoral link immunity in the blood, violation of cytokinogenesis, which predominated mainly at the 10th and 18th days of the experiment. It has been found out for the first time that in the dynamics (4th , 8th , 10th and 18th days) of the development of inflammatory processes in the lungs and parodontium there is a consistent increase of proteolytic processes under conditions of the antiprotease system depression in the lungs, which dominated in the later period (10th and 18th days) of their formation. It has been proved for the first time the immunoregulatory and antioxidative effect of thiotriazoline in disturbed indicators of immune and metabolic processes (reduction the content of conjugated dienes, malonic dialdehyde, circulating immune complexes, immunoglobulins A, M, G, B-lymphocytes, ІL-6 and an elevation activity of superoxide dismutase, catalase and glutathione peroxidase, levels of T-lymphocytes, IL-10, protease inhibitors in the lungs and blood) in experimental pneumonia combined with parodontitis.