Tul O. Pathomorphological characteristics of factorial infections of the sand lizard

hyperplasia of lymphoid nodules was found, which indicated their immunological rearrangement. A high pathogenicity rate of Escherichia coli STM-3, Staphylococcus epidermidis T-7S, Proteus vulgaris SL-91 pathogens with the laboratory animals’ mortality from 60% to 100% was established. In the white mice and rabbits’ body in bioassays using a pure culture suspension of Escherichia coli CTM-3, Staphylococcus epidermidis T-7S and Proteus vulgaris SL-91 strains it was found that intoxication of animals leads to impaired protein metabolism and hemodynamics, development of necroses, catarrhal inflammation of the mucous membrane in the middle and posterior canals of the digestive tract, formation of inflammatory infiltrates in the parenchymal organs, spleen, lymph nodes. On the basis of morphology studies in the sand lizard’s body, bacteriological and pathomorphological studies, pathogenetic mechanisms of changes in organs, morphogenesis of damage in the sand lizard’s factorial diseases and in experimentally infected laboratory animals are revealed. The above said improves awareness of the infectious process development in factorial diseases and can be used to organize diagnostic, treatment and preventive measures to combat infection. As a result of bacteriological studies of the sand lizard’s microflora, the obtained strains of Escherichia coli CTM-3 for veterinary biotechnology, Staphylococcus epidermidis T-7S for veterinary microbiology, Proteus vulgaris SL-91 were originally deposited in the Depository of the State Research and Control Institute of Biotechnology and Strains of Microorganisms and were confirmed by the Utility Model Patents of Ukraine No. 122173 and No. 122175. Key words: Escherichia coli, Proteus vulgaris, Staphylococcus epidermidis, associated course, bioassay, laboratory animals, pathomorphological changes, opportunistic pathogenic microflora, factorial infections, sand lizard.