Rabbits were in dispensary and the following indicators were examined in the complex: clinical; morphological (in the blood: the number of erythrocytes, leukocytes, mass of hemoglobin in erythrocyte, leukogram); biochemical (in the blood: the content of hemoglobin, total protein, total calcium, inorganic phosphorus, albumins, total cholesterol, total bilirubin, TBA-active products, activity in blood serum of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma-glutamyl transpeptidase, catalase); chemical composition (in blood plasma – Ca, Mn, Zn, Fe, Co, Cu, Mg; in whole blood – Ca, Mn, Pb, Cd; in urine – Ca, Mn, Pb, Cd, Fe, Zn, Co, Cu; in hair – Ca, Mn, Pb, Cd, Fe, Zn, Co, Cu; zootechnical ( ration analysis) and statistical. During the dispensation, it was established that the hemoglobin content in the rabbits' blood is 83.30±3.38 g/l, inorganic phosphorus is 0.77±0.04 mmol/l, and the number of erythrocytes is 4.90±0.15 T/l , MCH – 17.03±0.39 pg, which corresponds to the lower physiological limit. In the blood plasma of rabbits, the average content of elements is in mg/l: Mn 0.009±0.001; Fe 0.79±0.07; Zn 1.66±0.40; Co 0.0033±0.0004; Cu 0.25±0.052. In the blood plasma of rabbits, the average content of elements is in mg/l: Mn 0.007±0.001; Fe 0.76±0.11; Zn 0.66±0.08; Co 0.0033±0.0005; Cu 0.52±0.07. The average content of elements in rabbit hair is in mg/g: Mn 7.04±2.21, Fe 24.74±5.84, Zn 197.22±26.98, Co 0.057±0.012, Cu 11.27±1.50; in rabbit hair – Mn 11.27±1.50, Fe 28.33±7.68, Zn 219.59±32.01, Co 0.143±0.035, Cu 13.70±1.83. The average content of elements in the urine of rabbits is in mg/l: Mn 0.28±0.07, Fe 2.14±0.60, Zn 1.63±0.42, Co 0.06±0.01, Cu 0.25±0.05; in rabbit urine – Mn 0.05±0.01, Fe 1.46±0.38, Zn 0.98±0.23, Co 0.065±0.011, Cu 0.05±0.01. The correlation coefficient between the content in blood plasma and hair of New Zealand white rabbits is: Ca -0.42, Mn -0.32, Fe 0.63, Zn 0.40, Cu 0.39, which proves the informativeness of elemental analysis of hair for diagnosis disorders of the metabolism of mineral substances. A correlation coefficient of 0.33 between Ca content in whole blood and urine and 0.44 between Cu content in blood plasma and urine was also found, which adds to the knowledge about the development of mineral metabolism disorders in rabbits. For the prevention of mineral metabolism disorders in rabbits, a biologically active additive «Guminorm Plus» has been developed, which includes: glauconite, succinic acid, sodium salts of humic and fulvic acids, lactates of zinc, manganese, copper, cobalt and iron. А search was made for the most effective form and method of using the developed biologically active supplement for 21 days. The best prophylactic effectiveness was established by using the biologically active supplement «Guminorm Plus» with feed in the form of a powder for rabbits. The biologically active supplement «Guminorm Plus» was applied to rabbits during the second lactation with feed in the form of powder, daily, for 30 days and rabbits on fattening with feed for 50 days. Biologically active additive «Guminorm Plus» is effective for the prevention of mineral metabolism disorders. For comprehensive determination of the macro- and microelement status of the rabbit organism in the biological environment of small volumes (2.0 ml for liquid and 1.0 g for solid substances), it is recommended to use the method of atomic emission spectrometry with inductively coupled plasma (OES-ICP). For non-invasive diagnosis of disorders of mineral metabolism in rabbits, it is recommended to take hair samples by clipping them from the end of the tail, at least 1.0 g, with the color of the sample noted. To assess the mineral status of the rabbit's body, it is effective to examine calcium, manganese, iron, zinc, cobalt and copper in the hair. In order to prevent disorders of the metabolism of mineral substances in rabbits in the conditions of farms located in the biogeochemical province of Kyivske Polissia, we recommend using the biologically active additive «Guminorm plus» in the form of a powder for feeding with feed at a dose of 4 g per 1 kg of concentrated feed, preferably within 1.0-1.5 months.
