Chernetska N. Clinical and pathogenetic features and differentiated treatment of chronic obstructive pulmonary disease combined with diabetes mellitus type 2

The dissertation presents a theoretical generalization and a new solution to the current scientific and practical problem of internal diseases, which is to improve the treatment of patients with chronic obstructive pulmonary disease (COPD), combined with concomitant diabetes mellitus type 2 (DM 2), based on new scientific data clinical and pathogenetic features of this comorbidity by differentiated use of atorvastatin, taking into account the C3435T polymorphism of the MDR1 gene. Scientific data have been supplemented that patients with chronic obstructive pulmonary disease with concomitant type 2 diabetes are characterized by more pronounced shortness of breath and cough, increased production of sputum and its worse nature. It was found that the frequency of exacerbations, the number of ambulance calls due to exacerbation of the disease and hospitalization per year, the duration of inpatient treatment with lower spirometry are also higher (FEV1, PEF, MEF25, MEF50, МEF75, MMEF25-75, FEV1 / FVC, VC, MVV and slow VC). It has been reported that patients with chronic obstructive pulmonary disease with concomitant diabetes mellitus type 2 have higher body mass index, fat percentage, visceral fat level, bone mass, muscle mass and metabolic age. There is a decrease in exercise tolerance and a more severe course and prognosis of COPD according to the BODE index.