In the dissertation work on the basis of the results of a comprehensive examination of patients with generalized atherosclerosis (GAS) proved the relationship of serotonin in the blood with clinical manifestations of ischemia and volumetric blood flow in the affected vessels, proposed the introduction of cilostazol in the treatment of patients with GAS. According to the Recommendations of the European Society of Cardiology (ESC) the European Society for Vascular Surgery (ESVS), approved by the European Stroke Organization (ESO), generalized atherosclerosis or systemic atherosclerosis is a pathological condition in which there is atherosclerotic lesions of several vascular territories (2017 ESC Guidelines, 2018). According to the World Health Organization (WHO), the world's leading cause of death is cardiovascular disease (CVD). According to statistics, 17.9 million people died of CVD in 2018 in the world, among them, 85% were due to acute coronary syndrome (ACS) and stroke. Most, 75% of these deaths are recorded in low- and middle income countries (Benjamin, Emelia J., et al., 2019). In Ukraine, according to the State Statistics Service, in 2019 more than 580 thousand deaths were recorded, 67% of them - deaths from CVD, it`s about 400 thousand deaths. Among them, the main cause is atherosclerosis and atherothrombosis, which causes by coronary heart disease (CHD) and cerebrovascular diseases, which account for 67.5 and 21.8% of cases, respectively. The presence of GAS negatively affects the prognosis of patients. According to the Framingham study, vascular damage in several territories may be associated with a 2-3-fold increase in the risk of death from CHD (Members, Writing Group, et al., 2016; Townsend, Nick, et al., 2015). A recent study of approximately 28,000 patients with a history of CVD showed that patients with symptomatic peripheral artery disease but no myocardial infarction (MI) or stroke had twice the risk of CVD than those with MI or stroke, but had no symptomatic peripheral artery disease (Virani SS, et al., 2020). Despite the fact that the pathogenetic mechanisms of atherogenesis are the same, the degree of their activity may differ significantly, provided they are localized in different vascular areas. This is evidenced by the different degree of atheromatous stenosis of the arteries in different vascular territories in the same patient. Hemodynamic factors of central and peripheral hemodynamics are determining. Therefore, it is important to study the presence and severity of atheromatous changes, to assess the volume and velocity of blood flow in all available arteries.
