Zviahina O. Anemic syndrome in patients with ankylosing spondylitis

According to the results of an examination of 118 patients for the first time for a cohort of Ukrainian patients with ankylosing spondylitis found that anemic syndrome occurs in 34 (28.8 %) patients. Latent iron deficiency was registered in 10 (11.9 %) individuals with a hemoglobin level of at least 120 g/l. Mild anemia was found in 27 patients (79.4 %). In patients with AS, anemic syndrome is represented by ACD - in 44.1 % of patients, ACD with iron deficiency - in 29.4 % of patients and IDA - in 23.5 % of people. In terms of gender, anemic syndrome was more common in women (67.7 %) than in men (22.5 %). In the structure of the anemic syndrome with a peripheral form of AS there was a larger share of people with ACD (53.3 %) and ACD with iron deficiency (50.0 %) than among patients with a central form, and there were more people with anemia of II degree (57,1 %). For the first time it was found that patients with AS with anemia have greater activity of the inflammatory process according to the questionnaires BASDAI, ASDAS, visual analog scale (VAS). The presence of IDA in patients with AS was clearly associated with the minimum activity according to the BASDAI indices 5.40±0.46 points and ASDAS 3.95±0.29 points, while the presence of ACD was characterized by higher activity according to these questionnaires 7.42±0.25 and 4.44±0.11 points, respectively. Hepcidin levels in patients with anemia are 1.4 times higher than in the group of patients without anemia. The highest levels of hepcidin were in the group of patients with ACD 62.78±5.94 ng/ml, the lowest - with IDA 35.84±7.50 ng/ml, patients with ACD and iron deficiency had intermediate values 48.53±9.50 ng/ml. Deterioration of QOL and functional status were also correlated with anemic syndrome according to SF-36, HAQ and BASFI (r=0.13; r=-0.22; r=-0.24, p<0.05). ACD and ACD with iron deficiency are characterized by lower QOL rates than patients with IDA.